Lippes will produce a women's and men's range for spring 09 and autumn 09 called Adam for Mango. The limited edition collections will include denim, T-shirts, trousers, dresses, outerwear and accessories.
Lippes was creative director of Oscar de la Renta until 2003 and is now chief executive of Adam by Adam Lippes.
The spring range will go on sale in all Mango markets on March 15 2009.
The collaboration follows Mango's tie up with actress Penelope Cruz and her sister Monica for spring 08.
Mango opened 152 stores last year and plans to open 180 this year in Algeria, Belarus and Georgia.