The new design features new functions including a "shop by" facility. Customers can shop be catwalk look, event, style edit, trend and favourite five.
The site will also flag up "must haves" on its homepage on a daily basis to give customers newness each time they visit.
The site will also host a weekly vod-cast with style tips and style advice from the my-wardrobe.com buying team, its co-founder Sarah Curran as well as guest stylists and fashion experts.
The company will also introduce new packaging comprising of a branded shopping bag and tissue-wrapped purchases.
Launched in April 2006, the site has seen a 92% increase in visitors and a 143% increase in sales year-on-year.
Curran said: "It's been another phenomenal year for My-wardrobe.com with fantastic growth for both sales and visitors to the site, so we are delighted to be able to launch our brand new site design and packaging as we move into the third year of trading."
"We have focused on style and innovation with the design of the new site, helping to simplify and better the shopping experience. With the introduction of new features such as my-tv and my-blog, we wanted to be able to provide even more engaging quality content for our customers."
Sarah Curran is among the speakers at the Drapers Maximising Online Revenue conference which takes place on June 12 at The Radisson Mayfair in London. For more details and took book tickets go to http://www.emapconferences.co.uk/drapersonline/index.jsp