Selfridges’ Oxford Street store has lost its two deputy store directors within a week of each other.
Gianni Rappuoli has left after four years in the role while Katie Wyle had worked at the department store for less than two years.
Rappuoli, whose previous roles include two stints as a store manager for Gucci, is thought to be joining Dolce & Gabbana in China.
It is not known if Wyle, whose background includes store manager at Fortnum & Mason, has another role lined up.
A Selfridges spokeswoman confirmed the departures and said it was recruiting replacements. It is unclear whether any current staff will step up on an interim basis.
The spokeswoman added that David Jarvis, who has been at the retailer for 16 years, mostly in food, has been promoted to deputy store director for operations, but this does not replace either Rappuoli or Wyle. Store director Maeve Wall remains in place.
The exits follow several from earlier this year, the most high-profile of which was director of menswear Anita Barr, who gave notice in May.
She is being replaced this autumn by Terry Betts from etailer Mr Porter.