Longstanding Céline creative director Phoebe Philo is leaving the LVMH-owned label next month.
Philo, who is widely credited with reviving the brand, has held the post for almost 10 years after joining in October 2008. The autumn 18 collection will be her final presentation with Céline.
Before joining the label, Philo worked for nine years at Chloé until 2006, taking over as creative director in 2001 after Stella McCartney left the business.
Philo stepped down from her position at Chloé in 2006 to spend time with her family before joining Céline.
LMVH has not yet named a successor, WWD reported.
Analysts have speculated that Philo may reunite with former Céline chief executive Marco Gobbetti at Burberry, which he joined earlier this year after his appointment to the role in July 2016.
Christopher Bailey, Burberry’s chief creative officer at the time, left the brand in October.